Senior Bioinformatics Scientist – Personalis, Inc.
About PersonalisPersonalis, Inc. is a leader in advanced genomics for precision oncology. NeXT Personal is an ultra-sensitive, tumor-informed, WGS-based liquid biopsy assay designed to detect minimal residual disease (MRD) and cancer recurrence. It leverages whole-genome sequencing of a patient's tumor and matched normal samples to create a personalized panel of up to 1,800 somatic variants, enabling the detection of circulating tumor DNA (ctDNA) at very low levels (down to ~1-3 PPM) in blood samples.
Days Onsite: Monday & Tuesday
SummaryThe Senior Bioinformatics Scientist will work with a world-class, dynamic team of bioinformatics scientists, software engineers, and laboratory scientists, developing, testing, and applying cutting-edge cell-free and solid tumor cancer genomics products. You will work closely with clinical evidence generation teams, applying cell-free technology solutions to large cancer patient cohorts and profiling patient response to therapy. This position directly contributes to a new generation of genomics-based precision-medicine products.
Responsibilities
- Design and develop novel cell-free technologies and products.
- Collaborate closely with laboratory scientists to design experiments to develop and evaluate novel applications for cell-free DNA assays.
- Use genomics and statistics to model and improve performance of cell-free assays and features.
- Synthesize large datasets to develop and evaluate new biological and technological hypotheses.
- Partner with the clinical evidence generation team to ensure the applicability and evaluate the performance of novel assays or feature improvements.
- Maintain a strong working knowledge of literature covering technological developments in the cell-free DNA and liquid biopsy space.
- Publish results and present at conferences in areas including cell-free DNA and cancer genomics.
Requirements
- Advanced degree (Ph.D.) in bioinformatics, genomics, or a related field.
- Extensive experience with cancer genomics.
- Extensive experience with somatic mutational detection and filtering.
- Experience with cancer liquid biopsy analysis.
- Proficiency in the application of statistical methods to genomic applications.
- Proficiency with at least one common programming language (e.g., Python, R).
- Track record of designing and implementing experimental approaches to confirm and elaborate upon findings from complex projects.
- Experience publishing and presenting scientific results.
Compensation
- Hiring Range: $155,000 – $190,000 per year (may vary based on geographic region, internal equity, skills, and experience).
- Additional Benefits: Annual performance-based bonus (or sales incentive plan), long-term incentive units (equity), medical/financial benefits, 401(k) match, ESPP, tuition reimbursement, commuter benefits/EV charging stations, and onsite gym.
Equal Opportunity Employer: Personalis is an equal opportunity employer committed to the full inclusion of all individuals.
Protecting Our Candidates: Official correspondence comes exclusively from @personalis.com email addresses. Personalis will never ask for personal financial information or conduct interviews over text or chat platforms.
