Senior Scientist, Real-World Evidence, Oncology – BillionToOne
Role Overview
BillionToOne is seeking a Senior Scientist, Real-World Evidence (RWE), to join their team and unlock insights from a rapidly growing dataset of genomic profiles and real-world clinical data. This role sits at the intersection of AI, genomics, oncology research, and clinical data science. You will develop models and analytical approaches to transform genomic and clinical data into actionable insights for research, clinical decision support, and data-driven products.
A unique aspect of this role is the opportunity to work with BillionToOne’s proprietary dataset, which combines genomic sequencing results from their Northstar oncology platform with real-world medical records. You will report to the Chief Product Officer.
Responsibilities
- RWE Generation: Leverage integrated datasets of Northstar genomic sequencing results and real-world clinical data to generate clinically meaningful insights and real-world evidence (RWE).
- AI/ML Development: Develop AI and machine learning approaches that uncover patterns across genomic alterations, treatment histories, and patient outcomes to support internal research and improve how genomic test results inform clinical decision-making.
- Clinical Utility Tools: Build AI-powered tools that enhance the clinical utility of diagnostics, including systems that surface relevant medical records, literature evidence, clinical trials, and guideline information alongside Northstar test results to assist oncologists with personalized treatment decisions.
Qualifications
- Education: PhD in biology, biomedical sciences, medicine, computational biology, biomedical informatics, or a related field.
- Domain Expertise: Deep understanding of genomic data, oncology biology, and clinical medical data.
- Technical Skills: Strong programming and data science skills (Python and modern ML frameworks); ability to analyze and integrate multimodal biomedical datasets (genomics, clinical data, literature).
- AI/ML: Experience applying AI, machine learning, or advanced analytics to biomedical or healthcare datasets.
- Data Experience: Experience working with real-world clinical datasets (EHR, clinical records, registries, etc.).
- Collaboration: Strong problem-solving skills and ability to collaborate across interdisciplinary teams, including clinical, bioinformatics, and product groups.
Experience
- Experience working with oncology real-world datasets.
- Experience applying large language models (LLMs) or retrieval-based AI systems to biomedical knowledge extraction.
- Experience integrating genomic sequencing data with clinical outcomes data.
- Track record of research publications or applied AI systems in healthcare or life sciences.
Compensation
- Total Compensation Package: $251,855 per year.
- Base Pay Range: $139,340 – $160,777 per year.
- Note: Includes generous equity options and a corporate bonus program.
Benefits And Perks
- Healthcare: Multiple medical benefit options; employee premiums paid 100% on select plans, dependents covered at 80%.
- Family: Extremely generous Family Bonding Leave (16 weeks, 100% paid).
- Retirement: Savings program including a 4% company match.
- Work Environment: Open, transparent culture with weekly Town Hall meetings.
- On-Site Perks: Daily catered lunches, access to a state-of-the-art gym, and free EV charging.
- Equipment: Latest hardware (laptop, lab equipment, facilities).
About BillionToOne
BillionToOne is a next-generation molecular diagnostics company on a mission to make powerful, accurate diagnostic tests accessible to everyone. Their revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-free DNA.
- Impact: * Unity Complete™: The only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single sample.
- Northstar®: A liquid biopsy test combining treatment selection with real-time monitoring for oncology.
- Growth: Scaled from $0 to over $150M in Annual Recurring Revenue in five years. Completed one of the most successful IPOs for a medical diagnostics company in 2025.
- Recognition: Forbes named BillionToOne one of America's Best Startup Employers for 2025, and the company is Great Place to Work certified.
- Future: Headquartered in Menlo Park, with facilities in Union City, CA, and a new lab opening in Austin, TX, in 2027.
