ABOUT BILLIONTOONE
At BillionToOne, we've built a category-defining, publicly traded company on Nasdaq where transparency fuels trust, collaboration drives breakthroughs, and every contribution moves the needle on our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we build products that are 10x better than anything that exists today.
Our scientists, engineers, sales executives, and visionaries are united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion, and every innovation you contribute helps remove the fear of the unknown from some of life's most critical medical moments.
ABOUT THE ROLE
The Prenatal Reporting Clinical Laboratory Scientist (RCLS) is responsible for performing high-complexity clinical laboratory data analysis, reviewing and interpreting molecular diagnostic and sequencing results, and ensuring the accuracy, reliability, and timely reporting of patient results in accordance with established laboratory procedures and applicable regulatory requirements.
The RCLS independently executes validated bioinformatics pipelines, evaluates analytical results and quality control metrics, troubleshoots, and reviews and releases clinical laboratory reports within established authorization and reporting procedures. For complex or unusual results requiring additional evaluation, the RCLS collaborates with Bioinformatics, the Laboratory Directors, and other appropriate clinical personnel to ensure accurate interpretation and reporting.
In addition to routine clinical reporting responsibilities, the RCLS is expected to demonstrate technical leadership by exercising sound scientific judgment, independently investigating complex analytical issues, providing technical guidance to colleagues, supporting personnel training, and identifying opportunities for continuous process improvement.
This role is a hybrid work arrangement requiring approximately 60% on-site presence at the Union City and/or Menlo Park, CA offices (three days per week on-site and two days per week remote).
RESPONSIBILITIES
Analysis and Reporting (70%)
- Clinical Genomic Data Analysis and Interpretation:
- Execute established and validated bioinformatics pipelines to process and analyze molecular diagnostic data from patient samples.
- Independently review and interpret clinical genomic data, including sequencing results, bioinformatics outputs, and associated quality control metrics, to ensure results meet established quality standards and reporting criteria.
- Identify, investigate, and troubleshoot analytical discrepancies, unusual findings, and potential data quality issues, collaborating with Bioinformatics and other appropriate technical teams to resolve complex issues.
- Independently manage daily sample analysis priorities, monitor analytical workflows, and proactively communicate technical issues or concerns that may impact reporting accuracy or turnaround times.
- Clinical Reporting and Quality Review:
- Independently review, verify, and release clinical laboratory reports in accordance with established procedures, documented personnel authorization, and applicable regulatory requirements.
- Collaborate with other RCLSs, Bioinformatics, Genetic Counselors, Laboratory Directors, and other clinical personnel to evaluate complex findings, resolve reporting discrepancies, and obtain additional review or approval when necessary.
- Ensure the accuracy, completeness, and consistency of clinical reports while managing daily reporting priorities and maintaining established quality standards and turnaround time expectations.
- Maintain accurate documentation of analytical reviews, quality assessments, investigations, and reporting decisions.
- Communicate reporting concerns and unresolved issues promptly to appropriate personnel to support continuity of reporting operations.
Technical Leadership, Quality Assurance, and Operational Support (30%)
- Technical Leadership and Training:
- Exercise sound scientific judgment and demonstrate initiative and accountability in clinical data analysis and reporting.
- Independently investigate complex analytical discrepancies, troubleshoot technical issues, and identify appropriate solutions or escalation pathways.
- Serve as a technical resource for other Reporting CLS personnel by sharing knowledge, providing guidance, and supporting consistent application of procedures.
- Assist with training, onboarding, and mentoring Reporting CLS personnel and other clinical laboratory staff.
- Proactively identify opportunities to improve reporting accuracy, workflow efficiency, and overall laboratory performance.
- Participate in technical leadership activities, such as coordinating technical investigations, supporting validation projects, or contributing to workflow improvements.
- Quality Assurance and Regulatory Compliance:
- Perform and support QC and QA activities to maintain testing and reporting accuracy, reliability, and integrity.
- Ensure compliance with applicable CLIA, CAP, California state regulations, and established laboratory policies.
- Identify, document, and investigate quality-related issues, including analytical discrepancies, nonconforming results, and deviations from established procedures.
- Collaborate with Quality Management and leadership to support root cause investigations, CAPAs, and continuous quality improvement initiatives.
- Process Improvement and Workflow Optimization:
- Identify and recommend opportunities to optimize analytical workflows, improve reporting accuracy, and enhance operational efficiency.
- Collaborate with Laboratory Operations, Bioinformatics, Genetic Counselors, and Process Engineering to support the development, validation, implementation, and optimization of new/updated tests and reporting workflows.
- Assist with technology transfer and implementation of validated methodologies from Process Engineering into the clinical laboratory.
- Maintain and update reporting procedures, technical documentation, and workflow resources.
- Cross-Functional Collaboration and Operational Support:
- Collaborate with Laboratory Operations, Bioinformatics, Genetic Counseling, Client Services, Quality Assurance, and Process Engineering to resolve sample-specific and workflow issues.
- Serve as a technical point of contact for cross-functional teams addressing clinical reporting questions or troubleshooting analytical issues.
- Support laboratory leadership with reporting priorities, operational coordination, and project deliverables.
QUALIFICATIONS
- Licensure: Active and valid CLS or Clinical Genetic Molecular Biologist Scientist (CGMBS) license issued by the State of California, or licensed to practice medicine, osteopathy, or podiatry in California.
- Education: Bachelor's degree or higher in Biomedical Laboratory Sciences, Clinical Laboratory Science, Molecular Biology, Genetics, or a related scientific discipline consistent with licensure requirements.
- Experience: Minimum 1 year of clinical laboratory experience (or equivalent) in a high-complexity, high-volume molecular diagnostic clinical laboratory environment.
- Demonstrated experience with sequencing data analysis, including evaluation and interpretation of NGS results and associated analytical QC metrics.
- Demonstrated ability to independently analyze complex laboratory data, investigate discrepancies, and troubleshoot issues affecting test performance or reporting accuracy.
- Working knowledge of molecular biology principles, clinical testing methodologies, and local, state, and federal laboratory regulations (CLIA, CAP).
- Familiarity with bioinformatics analysis outputs and their application to clinical molecular diagnostic reporting.
- Strong computer skills, including laboratory data management systems, analytical software, Atlassian Suite, Google Workspace, and Microsoft Office Suite.
- Strong analytical judgment, attention to detail, and organizational and problem-solving skills.
- Excellent written and verbal communication skills with the ability to collaborate effectively across multidisciplinary teams.
COMPENSATION & BENEFITS
- Compensation Package: Total compensation up to $168,755 per year, including a base pay range of $127,991 – $149,323 per year, plus generous equity options and corporate bonus program.
- Health & Wellness: Multiple medical benefit options (100% employee premiums paid for select plans, dependents covered up to 80%).
- Parental Leave: 16 weeks of fully paid Family Bonding Leave for new parents; supplemental fertility benefits coverage.
- Retirement: Savings program with 4% company match.
- Onsite Perks: Daily lunches from top eateries, state-of-the-art gym, restaurant on campus, free EV charging.
- Time Off: Increasing paid time off with tenure.
