10x Genomics is establishing a diagnostics effort to translate its leading single-cell and spatial genomics technologies into impactful clinical applications. This position performs and provides scientific and technical oversight for high-complexity next-generation sequencing (NGS) assays within a CLIA-certified laboratory.
The Technical Supervisor serves as the subject matter expert for assay validation, quality systems, and troubleshooting, partnering closely with laboratory leadership to maintain operational excellence and continuous improvement.
Role Overview
- Position: Clinical Laboratory Scientist / Technical Supervisor (NGS Diagnostics)
- Location: Onsite
- Base Compensation Range: $158,400 - $214,400 / year
This role is accountable for ensuring the operational execution, analytical validity, performance, and regulatory compliance of all clinical NGS testing.
Responsibilities
Technical Oversight & Operations
- Provide operational execution and technical oversight of high-complexity NGS assays, ensuring analytical accuracy and reliability of test results.
- Serve as the primary technical resource for troubleshooting complex assay, instrumentation, and bioinformatics issues.
- Evaluate and approve changes to assays, workflows, instrumentation, and software, including revalidation as required.
- Oversee proficiency testing, method comparisons, and ongoing assay performance monitoring.
- Provide technical training and competency assessments for laboratory personnel.
Quality Assurance & Compliance
- Validate and implement NGS assays in accordance with CLIA, CAP, and applicable regulatory standards.
- Establish and monitor quality control (QC) and quality assurance (QA) programs, including the review of performance metrics, trends, and corrective actions.
- Author, review, and approve technical documentation, including standard operating procedures (SOPs), validation protocols/reports, and test methods.
- Ensure compliance with all regulatory requirements and support internal and external audits and inspections.
Cross-Functional Collaboration
- Partner with cross-functional teams (Bioinformatics, R&D, Quality, and Operations) to support assay optimization and innovation.
- Stay current with emerging technologies, regulatory updates, and best practices in NGS and molecular diagnostics.
Required Qualifications
- Licensure: Active California Clinical Laboratory Scientist (CLS) license meeting CLIA requirements for Technical Supervisor of high-complexity testing.
- CLIA Alignment: Meets CLIA Technical Supervisor qualifications under 42 CFR 493.1449, including appropriate education, training, and experience.
- Education: Bachelor’s degree in chemical, biological, physical, clinical laboratory science, or a related field.
- Experience: Minimum of 4–6 years of experience in a CLIA-certified molecular diagnostics laboratory.
- Technical Expertise: Significant experience in NGS assay validation, implementation, and operation, including library preparation, sequencing platforms, and bioinformatics analysis pipelines.
- Regulatory Knowledge: Strong knowledge of CLIA, CAP, NYS, and other regulatory frameworks governing high-complexity testing.
Preferred Attributes
- Prior experience serving specifically as a CLIA Technical Supervisor.
- Experience working within a startup or high-growth laboratory environment.
- A strong background in medical or oncology diagnostics.
- Excellent analytical, problem-solving, and decision-making skills.
- Strong written and verbal communication skills, with the ability to convey complex technical concepts clearly.
Compensation & Total Rewards
The hiring range for this position is $158,400 to $214,400 USD per year, depending on unique skills, qualifications, and experience.
In addition to base pay, 10x Genomics offers a comprehensive total rewards package:
- Equity grants
- Comprehensive health benefits
- Retirement benefit programs
- Annual bonus program or sales incentive program
Equal Opportunity & Security Protections
Candidate Security Notice: Please be aware of recruitment scams impersonating 10x Genomics. All official recruiting communication will come exclusively from email addresses ending in @10xgenomics.com. Candidates are encouraged to apply directly via Careers.10xgenomics.com. The company will never request payment or sensitive personal financial information during the recruiting process.
10x Genomics is an Equal Opportunity Employer. Individuals seeking employment are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, sexual orientation, or any other characteristic protected by applicable law.
