Clinical Genomics Scientist, Oncology – BillionToOne
Role Overview
BillionToOne is seeking a Clinical Genomics Scientist to support the Clinical Genomics team in day-to-day commercial reporting operations, specifically focusing on variant interpretation and report drafting. This is a part-time, remote-based contracting position (10–20 hours/week) requiring a commitment of at least one year.
Key Logistics
Position Type - Part-time Contracting
Commitment - 10–20 hours/week (Minimum 1-year engagement)
Location - Remote
Availability - Must be able to work Saturday and/or Sunday
Rate - $100/hour
Responsibilities
- Somatic Variant Interpretation: Perform somatic-based variant interpretation by reviewing literature and databases to classify variants and match treatments. Perform verifications using BAM file analysis.
- Clinical Report Drafting: Draft reports using an in-house reporting API, working in coordination with engineering, QA, and laboratory directors.
- Content Curation: Contribute to the curation of gene-level content, such as domain and critical residue curation.
- R&D Collaboration: Work with the R&D team on somatic oncology projects, providing expertise on biological pathways, mechanisms, and variant-level analyses.
Qualifications
- Education: Ph.D. in Human Genetics, M.S. in Genetic Counseling, or a related field.
- Experience: 2+ years of experience in somatic variant interpretation based on ACMG/AMP guidelines (or 1+ years of germline and 1+ years of somatic experience).
- Technical Skills: * Hands-on experience with mutation databases (COSMIC, ClinVar, OncoKB), annotation sources (dbSNP), and genome browsers (UCSC).
- Familiarity with IGV and BAM file analysis.
- Willingness to learn basic bioinformatics tools and apply technically-minded insights.
- Domain Knowledge: Understanding of cancer somatic mutations and signaling pathways (e.g., FDA-approved drugs, clinical trials, and "hot targets").
- Attributes: Exceptional attention to detail for following SOPs and strong organizational skills for managing reporting projects.
About BillionToOne
BillionToOne is a next-generation molecular diagnostics company on a mission to make accurate diagnostic tests accessible to everyone. Their revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-free DNA.
- Impact:
- Unity Complete™: The only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single sample.
- Northstar®: A liquid biopsy test combining treatment selection with real-time monitoring for oncology.
- Growth: Scaled from $0 to over $150M in Annual Recurring Revenue in five years; completed a successful IPO in 2025.
- Recognition: Named one of America's Best Startup Employers for 2025 by Forbes and Great Place to Work certified.
- Future: Headquartered in Menlo Park, with facilities in Union City, CA, and a new lab opening in Austin, TX, in 2027.
